Anti-diphtheria antibody seroprotection rates are similar 10 years after vaccination with dTpa or DTPa using a mathematical model.

Abstract

The reduced antigen content diphtheria, tetanus and pertussis (dTpa) vaccine (Boostrixtrade mark) has been shown to induce a strong booster response to all the vaccine components in 4-6 year olds. However, anti-diphtheria antibody levels were observed to be lower when compared to the "full strength" paediatric DTPa vaccine. To assess the impact of this difference on long-term protection, a mathematical model was developed to predict diphtheria antibody decay over time. The model was based on a linear decrease in log-transformed antibody concentrations after the first year post-vaccination. When applied to data collected 3.5 years after vaccination of 4-6 year olds with either DTPa or dTpa, the model predicted that 10 years post-vaccination, 98.6% of subjects vaccinated with dTpa were likely to remain seroprotected against diphtheria, compared to 99.6% vaccinated with DTPa. Therefore, the difference observed in diphtheria antibody geometric mean concentrations 1 month after booster vaccination at 4-6 years with dTpa or DTPa is unlikely to be of clinical relevance 10 years later at the time of the adolescent booster.

• Authors: Brigitte Cheuvart, Margaret Burgess, Fred Zepp, Jussi Mertsola, Joanne Wolter, Lode Schuerman
• Journal: Vaccine (Vaccine) Vol. 23 Issue 3 Pg. 336-42 (Dec 02 2004) ISSN: 0264-410X [Print] Netherlands
• PMID: 15530678 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antibodies, Bacterial
• Diphtheria-Tetanus-Pertussis Vaccine

Topics

• Adult
• Antibodies, Bacterial (blood)
• Child
• Child, Preschool
• Cohort Studies
• Diphtheria (immunology)
• Diphtheria-Tetanus-Pertussis Vaccine (immunology)
• Humans
• Immunization Schedule
• Immunization, Secondary
• Models, Biological
• Randomized Controlled Trials as Topic
• Time Factors
• Vaccination (methods)