Abstract | BACKGROUND: MATERIALS: Forty-five renal transplant recipients with hyperlipidemia were enrolled in this study. The mean age was 44.2 years, with 23 men and 22 women. Thirty-seven transplantations were from a living related donors and eight from cadaveric donors. Thirty-three recipients were ABO-compatible, seven recipients had minor mismatches, and five recipients were ABO-incompatible. The dose of fluvastatin was 20 mg per day. Levels of total cholesterol (TC), triglyceride (TG), HDL cholesterol (HDL-C), LDL cholesterol ( LDL-C), serum creatinine (s-Cr), ALT, ALP, uric acid (UA), hematocrit (Ht), CPK, and blood pressure were examined in all recipients before treatment as well as 1, 3, and 6 months after Fluvastatin administration. RESULTS: The mean levels of TC and TG were significantly reduced from 256, to 224 and 215 mg/dL, and from 188 to 170 and 147 mg/dL at 1 and 6 months after treatment, respectively. The mean levels of HDL-C were 72 mg/dL before treatment, 81 mg/dL at 1 month, and 80 mg/dL at 6 months after treatment. The mean levels of LDL-C were 153 mg/dL before treatment, 145 mg/dL at 1 month, and 145 mg/dL at 6 months after treatment. Fluvastatin significantly produced a reduction rate in TC of 16%, TG of 22%, and LDL-C of 5% after 6 months of treatment, respectively. The mean levels of HDL-C of were increased 10% after 6 months of treatment. The serum creatinine and CPK were not significantly different. There were no clinically significant differences in other factors. No significant adverse effects were observed. CONCLUSIONS:
Fluvastatin seemed to be safe and highly effective to control TC, TG, LDL-C, and HDL-C in renal transplant recipients.
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Authors | T Tokumoto, K Tanabe, H Ishida, H Shimmura, N Ishikawa, N Goya, T Akiba, H Toma |
Journal | Transplantation proceedings
(Transplant Proc)
Vol. 36
Issue 7
Pg. 2141-4
(Sep 2004)
ISSN: 0041-1345 [Print] United States |
PMID | 15518777
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Anticholesteremic Agents
- Cholesterol, HDL
- Cholesterol, LDL
- Fatty Acids, Monounsaturated
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Indoles
- Triglycerides
- Fluvastatin
- Cholesterol
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Topics |
- Adult
- Anticholesteremic Agents
(adverse effects, therapeutic use)
- Blood Pressure
(drug effects)
- Cholesterol
(blood)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Fatty Acids, Monounsaturated
(pharmacokinetics, therapeutic use)
- Female
- Fluvastatin
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(pharmacokinetics, therapeutic use)
- Hyperlipidemias
(drug therapy, etiology)
- Indoles
(pharmacokinetics, therapeutic use)
- Kidney Transplantation
- Male
- Middle Aged
- Postoperative Complications
(drug therapy)
- Triglycerides
(blood)
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