The efficacy of combined low dose of Allopurinol and benzbromarone compared to standard dose of Allopurinol in hyperuricemia.

Abstract

OBJECTIVE:

To compare the efficacy of combined low dose of hypouricemic drugs (Allopurinol 100 mg and benzbromarone 20 mg; Allomaron) and standard dose 300 mg of allopurinol in hyperuricemia.

MATERIAL AND METHOD:

A prospective, open study of 94 hyperuricemic patients was done at King Chulalongkorn Memorial Hospital. Each group of 47 patients was given a combined low dose of hypouricemic drugs (Allopurinol 100 mg and benzbromarone 20 mg; Allomaron) and a standard dose 300 mg of allopurinol. Serum uric acid was measured before and 4 weeks after receiving the drugs. The efficacy was measured from the difference of the level of serum uric acid before and after receiving the drugs.

RESULTS:

The patients receiving the combined low dose of hypouricemic drugs and standard dose of allopurinol showed a mean reduction of serum uric acid of 2.5+/-3.4 mg/dl and 4.1+/-2.7 mg/dl consecutively. There was a statistically significant difference between the 2 groups (P = 0.010).

CONCLUSION:

This study demonstrates that the efficacy of standard dose 300 mg of allopurinol is superior to a combined low dose of allopurinol and benzbromarone in lowering the level of serum uric acid level.

• Authors: Somchai Akkasilpa, Manathip Osiri, Utis Deesomchok, Yingyos Avihingsanon
• Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai) Vol. 87 Issue 9 Pg. 1087-91 (Sep 2004) ISSN: 0125-2208 [Print] Thailand
• PMID: 15516011 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Gout Suppressants
• Uricosuric Agents
• Uric Acid
• Benzbromarone
• Allopurinol

Topics

• Allopurinol (administration & dosage)
• Benzbromarone (administration & dosage)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Drug Therapy, Combination
• Female
• Gout (blood, drug therapy)
• Gout Suppressants (administration & dosage)
• Humans
• Male
• Middle Aged
• Prospective Studies
• Treatment Outcome
• Uric Acid (blood)
• Uricosuric Agents (administration & dosage)