Abstract | OBJECTIVE: METHODS AND RESULTS: Wild-type and hypercholesterolemic female mice with >20-fold higher plasma levels of plant sterols because of inactivation of the ATP-binding cassette (ABC) half transporters G5 and G8 (G5G8-/-mice) were fed chow or Western diets for 7 months. No significant differences in aortic lesion area were found when the sitosterolemic mice were compared with littermate controls. To determine whether plasma levels of plant sterols were associated with coronary atherosclerosis in humans, the relationship between plasma plant sterols and coronary calcium (detected by electron beam computer tomography) was examined in 2542 subjects aged 30 to 67 years. Plasma levels of cholesterol, but not sitosterol or campesterol, were significantly higher in subjects with coronary calcium. CONCLUSIONS:
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Authors | Kenneth R Wilund, Liqing Yu, Fang Xu, Gloria L Vega, Scott M Grundy, Jonathan C Cohen, Helen H Hobbs |
Journal | Arteriosclerosis, thrombosis, and vascular biology
(Arterioscler Thromb Vasc Biol)
Vol. 24
Issue 12
Pg. 2326-32
(Dec 2004)
ISSN: 1524-4636 [Electronic] United States |
PMID | 15514206
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Adult
- Animals
- Aorta
(pathology)
- Aortic Diseases
(blood)
- Arteriosclerosis
(blood, ethnology)
- Coronary Disease
(blood, ethnology)
- Exons
(genetics)
- Female
- Humans
- Introns
(genetics)
- Male
- Mice
- Mice, Inbred AKR
- Mice, Inbred Strains
- Plant Extracts
(blood)
- Sterols
(blood)
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