Loss of caspase-2, -6 and -7 expression in gastric cancers.

Abstract

Caspases play an essential role during apoptotic cell death, and alterations of caspases are known to contribute to human cancer development. In the current study, we analyzed the expression of caspase-2, -6 and -7 in 120 gastric carcinomas by immunohistochemistry using a tissue microarray approach. Caspase-2, -6 and -7 were expressed in 42 (35%), 63 (53%) and 39 (33%) of the gastric cancers, respectively. By contrast, the surface mucous cells and mucosal glandular cells in the normal gastric mucosa showed strong immunoreactivity for caspase-2, -6 and -7. Taken together, these results indicate that caspase-2, -6 and -7 expression in gastric cancer cells is decreased compared to in normal gastric mucosal cells, and suggest that loss of caspase-2, -6 and -7 expression might be involved in the mechanisms of gastric cancer development.

• Authors: Nam Jin Yoo, Jong Woo Lee, Yun Ju Kim, Young Hwa Soung, Su Young Kim, Suk Woo Nam, Won Sang Park, Jung Young Lee, Sug Hyung Lee
• Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica (APMIS) Vol. 112 Issue 6 Pg. 330-5 (Jun 2004) ISSN: 0903-4641 [Print] Denmark
• PMID: 15511269 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CASP2 protein, human
• CASP6 protein, human
• CASP7 protein, human
• Caspase 2
• Caspase 6
• Caspase 7
• Caspases
• Cysteine Endopeptidases

Topics

• Caspase 2
• Caspase 6
• Caspase 7
• Caspases (metabolism)
• Cysteine Endopeptidases (metabolism)
• Down-Regulation
• Gastric Mucosa (enzymology)
• Humans
• Immunohistochemistry
• Protein Array Analysis
• Stomach Neoplasms (enzymology)