[Expression and significance of granulocyte-macrophage colony-stimulating factor receptors in human prostate cancer].

Abstract

OBJECTIVE:

To study the expression and significance of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors in human prostate cancer.

METHODS:

SP immunohistochemical method was employed to investigate the expression of alpha subunit of GM-CSF receptors in 48 cases of primary prostate cancer, 20 benign prostate hyperplasia samples and four kinds of cancer cell lines K562, PC-3M, HL-60 and MCF-7.

RESULTS:

The total positive percentage of GM-CSF expression in prostate cancer was 79.2%. The positive percentages in the groups with Gleason score 2-4, 5-8, and 9-10 were 75%, 82.3% and 81.2% respectively. The four kinds of cancer cell lines had prominent GM-CSF receptor alpha subunit expression.

CONCLUSION:

It suggests that both hyperplastic and neoplastic prostate tissues are responsive to GM-CSF and the extensive expression of GM-CSF receptors is an important characteristic of prostate cancer.

• Authors: Zhaohui Chen, Yu Yang, Yajun Xiao, Jun Zhao
• Journal: Zhonghua nan ke xue = National journal of andrology (Zhonghua Nan Ke Xue) Vol. 10 Issue 9 Pg. 655-7 (Sep 2004) ISSN: 1009-3591 [Print] China
• PMID: 15497703 (Publication Type: English Abstract, Journal Article)

Chemical References

• Receptors, Granulocyte-Macrophage Colony-Stimulating Factor

Topics

• Animals
• Blotting, Western
• Cell Line, Tumor
• HL-60 Cells
• Humans
• Immunohistochemistry
• K562 Cells
• Male
• Prostatic Hyperplasia (metabolism)
• Prostatic Neoplasms (metabolism, pathology)
• Rabbits
• Receptors, Granulocyte-Macrophage Colony-Stimulating Factor (biosynthesis)