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Prediction of outcome in infants with congenital diaphragmatic hernia or severe diaphragmatic eventration.

Abstract
Congenital diaphragmatic hernia (CDH) and severe congenital diaphragmatic eventration (SDE) still have high mortality. Our aims were to identify clinical prognostic factors for CDH and SDE, and to determine whether the size or area of the proximal bilateral pulmonary arteries (PA) correlate with the clinical outcome. We retrospectively analyzed medical charts of 26 patients--20 with CDH and 6 with SDE, but no obvious other associated anomalies--admitted over a 12-year period. We compared prenatal history, clinical manifestations, blood gas, and echocardiography before surgery in the survivors and the non-survivors. Ten patients (8 CDH, 2 SDE) died 2 to 16 days after birth, including 2 patients without surgery due to progressive hypoxemia. The survivors had significantly higher 1- and 5-min Apgar scores, higher the worst preductal arterial blood gas pH levels, lower oxygen indices, and lower PaCO2 (P < 0.05). The McGoon index of PA size measured by echocardiography was higher in survivors, but not statistically significant. Nakada PA index results, however, were statistically significant (93.07 +/- 32.02 vs. 121.07 +/- 27.08, P < 0.05) In conclusion, Apgar scores, preductal PaCO2, oxygen index, and pH level can predict prognosis in infants with CDH and SDE. The Nakada PA index, however, might be a useful prognostic marker for patients with CDH and SDE.
AuthorsChih-Ta Yao, Jieh-Neng Wang, Chyi-Her Lin, Cheng-Nan Yeh, Ying-Tai Tai, Ming-Ho Wu, Jing-Ming Wu
JournalActa paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi (Acta Paediatr Taiwan) Vol. 45 Issue 3 Pg. 131-5 ( 2004) ISSN: 1608-8115 [Print] China (Republic : 1949- )
PMID15493730 (Publication Type: Journal Article)
Topics
  • Apgar Score
  • Birth Weight
  • Blood Gas Analysis
  • Diaphragmatic Eventration (complications, pathology)
  • Electrocardiography
  • Female
  • Gestational Age
  • Hernia, Diaphragmatic (complications, pathology)
  • Hernias, Diaphragmatic, Congenital
  • Humans
  • Hypoxia (etiology)
  • Infant, Newborn
  • Lung (pathology, physiopathology)
  • Male
  • Retrospective Studies
  • Survival Analysis

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