Abstract | BACKGROUND: AIM: To assess H. pylori infection and success of H. pylori therapy by means of sPGII levels. METHODS: sPGII levels were determined in 156 H. pylori-positive and 157 H. pylori-negative consecutive patients with dyspeptic symptoms. Additionally, sPGII determination was performed in 70 H. pylori-positive patients 2 months after H. pylori eradication therapy. In 29 of these 70 patients, gastroscopy was performed to evaluate the effect of H. pylori therapy on gastric activity. RESULTS: H. pylori-positive subjects demonstrated a significantly higher mean of sPGII levels than H. pylori-negative subjects (16.8 +/- 7.4 vs. 8.6 +/- 3.7 microg/l; p < 0.001). The best sPGII cut-off for predicting H. pylori infection was 9.93 microg/l (sensitivity 83%, specificity 73%). The best cut-off values to evaluate success of therapy were: sPGII of 9.47 microg/l, a sPGII variation level (difference between baseline and after therapy) of 4.54 microg/l, and a sPGII Deltavalue (sPGII variation divided by sPGII before therapy) of 25% (sensitivity 93%, specificity 91%). CONCLUSIONS: sPGII levels may be used as a reliable marker of H. pylori infection in the initial diagnosis as well as to evaluate H. pylori eradication and subsequent changes in gastric inflammation.
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Authors | Francesco Di Mario, Ali Mahamat Moussa, Lucas Giovanni Cavallaro, Pietro Caruana, Roberta Merli, Simone Bertolini, Veronica Iori, Giulia Martina Cavestro, Nadia Dal Bò, Alberto Pilotto, Angelo Franzé, Gioacchino Leandro |
Journal | Digestion
(Digestion)
Vol. 70
Issue 3
Pg. 167-72
( 2004)
ISSN: 0012-2823 [Print] Switzerland |
PMID | 15479977
(Publication Type: Journal Article)
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Copyright | Copyright 2004 S. Karger AG, Basel. |
Chemical References |
- Anti-Bacterial Agents
- Anti-Ulcer Agents
- Biomarkers
- Pepsinogen C
|
Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Anti-Bacterial Agents
(therapeutic use)
- Anti-Ulcer Agents
(therapeutic use)
- Biomarkers
(blood)
- Enzyme-Linked Immunosorbent Assay
- Female
- Helicobacter Infections
(blood, drug therapy)
- Helicobacter pylori
- Humans
- Male
- Middle Aged
- Pepsinogen C
(blood)
- Treatment Outcome
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