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[Serial MEG change in a boy with Landau-Kleffner syndrome].

Abstract
We report a 7-year-old boy with Landau-Kleffner syndrome (LKS), with emphasis on the effect of therapy and serial MEG. The equivalent current dipoles (ECDs) of spike discharges accumulated in the bilateral Heschl gyri, predominantly on the right. Although spike discharges on the scalp EEGs disappeared by treatment with clonazepam and sodium valproate, the auditory agnosia did not improve. Therapeutic trials with conventional antiepileptic drugs were unsuccessful. A high-dose corticosteroid was effective, with disappearance of ECDs, appearance of auditory evoked fields (AEF) in the bilateral Heschl gyri on MEG, and improvement of behavioral problems and amelioration of acquired aphasia. The clinical course of this patient suggests that MEG findings are useful not only in making precise diagnosis of LKS but also in assessing and predicting the effects of treatment.
AuthorsTakanori Kamimura, Osamu Kanazawa, Jun Tohyama, Noriyuki Akasaka, Makoto Uchiyama
JournalNo to hattatsu = Brain and development (No To Hattatsu) Vol. 36 Issue 5 Pg. 395-400 (Sep 2004) ISSN: 0029-0831 [Print] Japan
PMID15461028 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Anticonvulsants
  • Clonazepam
  • Valproic Acid
  • Prednisolone
  • Methylprednisolone
Topics
  • Anticonvulsants (administration & dosage)
  • Child
  • Clonazepam (administration & dosage)
  • Drug Therapy, Combination
  • Evoked Potentials, Auditory
  • Humans
  • Landau-Kleffner Syndrome (diagnosis, drug therapy)
  • Magnetoencephalography
  • Male
  • Methylprednisolone (administration & dosage)
  • Predictive Value of Tests
  • Prednisolone (administration & dosage)
  • Pulse Therapy, Drug
  • Treatment Outcome
  • Valproic Acid (administration & dosage)

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