Abstract | OBJECTIVE: We sought to evaluate whether taurine detection in short-echo (20 ms) proton magnetic resonance spectroscopy contributes to the noninvasive differential diagnosis between medulloblastoma and cerebellar astrocytoma in children and young adults. These two types of tumor have very different prognoses and may be difficult to differentiate by neuroradiological or clinical means. METHODS: Single-voxel proton magnetic resonance spectra of tumors were acquired at 1.5 T in 14 patients with biopsy-proven primary cerebellar tumors (six medulloblastomas, seven astrocytomas, and one mixed astroependymoma) using short-echo time (20 ms) and long-echo time (135 ms). For taurine assignment, qualitative analysis was performed on short-echo time spectra and results were compared in vitro with spectra of model solutions. Perchloric acid extracts of postsurgical tumor biopsies were performed in two medulloblastoma cases. RESULTS: CONCLUSION:
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Authors | Angel Moreno-Torres, Irene Martínez-Pérez, Miguel Baquero, Jaume Campistol, Antoni Capdevila, Carles Arús, Jesus Pujol |
Journal | Neurosurgery
(Neurosurgery)
Vol. 55
Issue 4
Pg. 824-9; discussion 829
(Oct 2004)
ISSN: 1524-4040 [Electronic] United States |
PMID | 15458590
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Astrocytoma
(diagnosis)
- Cerebellar Neoplasms
(diagnosis)
- Child
- Child, Preschool
- Diagnosis, Differential
- Humans
- Infant
- Medulloblastoma
(diagnosis)
- Nuclear Magnetic Resonance, Biomolecular
(methods)
- Protons
- Taurine
(analysis)
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