[Proliferation of fat cells in lipomas].

Abstract

Common lipomas and destructive ones (intramuscular, infiltrating, necrotizing and destroying surrounding tissues) were studied in 9 patients electron-microscopically and radioautographically. The adequacy of necrotizing processes and regeneration was observed: normal fat tissue-lipoma-destructive lipoma. In the latter besides pronounced destruction of tissue (adipocytes, vessels, muscles at the border with tumour), there was accelerated differentiation of preadipocytes from the cells-precursors (fibroblasts and undifferentiated cells of the vascular wall), hypertrophy of preadipocytes (their size and number of nuclei increase) and their proliferation. The process of malignant transformation in a destructive lipoma may be so much pronounced that DNA synthesis may be observed in the mature lipocyte (this has not been described so far).

• Authors: E G Kolokol'chikova, A A Pal'tsyn, A I Shchegolev, A A Adamian, N V Chervonskaia, A K Badikova
• Journal: Arkhiv patologii (Arkh Patol) 2004 Jul-Aug Vol. 66 Issue 4 Pg. 27-30 ISSN: 0004-1955 [Print] Russia (Federation)
• Vernacular Title: O proliferatsii zhirovykh kletok v lipomakh.
• PMID: 15449685 (Publication Type: English Abstract, Journal Article)

Chemical References

• DNA

Topics

• Adipocytes (chemistry, metabolism, pathology)
• Adult
• Cell Proliferation
• Cell Transformation, Neoplastic (chemistry, pathology)
• DNA (analysis, metabolism)
• Female
• Humans
• Lipoma (metabolism, pathology)
• Male
• Middle Aged