Administration of anti-TNF antibody improves left ventricular function in septic shock patients. Results of a pilot study.

Abstract

In this pilot study, murine monoclonal anti-TNF antibody (2 mg/kg) was administered to ten patients within 24 h of septic shock which persisted after initial resuscitation with intravenous fluids and adrenergic agents. This treatment resulted in a reduction in heart rate (from 122 +/- 10 to 113 +/- 10 beats per minute at 4 h, p less than 0.01) associated with an increase in LVSWI (from 26.5 +/- 5.6 to 31.5 +/- 10.5 g.m2 at 2 h, p less than 0.05), indicating in the absence of change in cardiac filling pressures, an improvement in ventricular function. Arterial oxygenation improved concurrently in six patients. These changes, however, appeared transient. The improvement in cardiac function following anti-TNF antibody administration in patients is in keeping with recent experimental studies indicating the role of TNF in the myocardial depression characterizing septic shock.

• Authors: J L Vincent, J Bakker, G Marécaux, L Schandene, R J Kahn, E Dupont
• Journal: Chest (Chest) Vol. 101 Issue 3 Pg. 810-5 (Mar 1992) ISSN: 0012-3692 [Print] United States
• PMID: 1541150 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Antibodies, Monoclonal
• Tumor Necrosis Factor-alpha

Topics

• Aged
• Antibodies, Monoclonal (therapeutic use)
• Female
• Humans
• Male
• Middle Aged
• Pilot Projects
• Resuscitation
• Shock, Septic (physiopathology, therapy)
• Tumor Necrosis Factor-alpha (immunology)
• Ventricular Function, Left