Case report: fulminant hepatitis C viral infection after allogeneic bone marrow transplantation.

Abstract

The authors describe two patients with acute leukemia who died of fulminant hepatitis caused by hepatitis C virus (HCV) after an allogeneic bone marrow transplant, the first such cases reported in Japan. Both had developed posttransfusion hepatitis during chemotherapy to induce remission and for consolidation. Six months after blood transfusion, the blood serum of each patient was positive for HCV antibody and HCV RNA. In each case, there was a transient improvement in liver function after the transplant. However, within 5 months of receiving the transplant and coincident with the withdrawal of cyclosporin A, each patient developed an acute exacerbation of hepatitis. The fulminant hepatitis in our patients may, therefore, have been caused by the reactivation of HCV induced by the immunosuppressive therapy followed by a reconstitution of the immune system.

• Authors: H Kanamori, H Fukawa, A Maruta, H Harano, F Kodama, M Matsuzaki, H Miyashita, S Motomura, T Okubo, M Yoshiba
• Journal: The American journal of the medical sciences (Am J Med Sci) Vol. 303 Issue 2 Pg. 109-11 (Feb 1992) ISSN: 0002-9629 [Print] United States
• PMID: 1539606 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cyclosporine

Topics

• Adult
• Bone Marrow Transplantation (adverse effects)
• Cyclosporine (adverse effects)
• Female
• Hepatitis C (etiology)
• Humans
• Leukemia, Lymphoid (surgery)
• Leukemia, Myeloid, Acute (surgery)
• Male