Reversible inflammatory and vacuolar myopathy with vitamin E deficiency in celiac disease.

Abstract

We report a patient with late-onset celiac disease and neurological manifestations including myopathy, polyneuropathy, and ataxia. Laboratory investigations showed anti-gliadin antibodies and severe vitamin E deficiency. Muscle biopsy revealed inflammatory infiltrates and rimmed vacuoles, similar to those found in inclusion-body myositis. A gluten-free diet and vitamin E supplementation reversed both the clinical neurological manifestations and the abnormalities in the muscle biopsy. Anti-gliadin antibodies were no longer present. This case illustrates the spectrum of neurological complications of celiac disease and documents the occurrence of reversible pathology resembling inclusion-body myopathy in the muscle.

• Authors: Kleopas A Kleopa, Kyriacos Kyriacou, Eleni Zamba-Papanicolaou, Theodoros Kyriakides
• Journal: Muscle & nerve (Muscle Nerve) Vol. 31 Issue 2 Pg. 260-5 (Feb 2005) ISSN: 0148-639X [Print] United States
• PMID: 15389648 (Publication Type: Case Reports, Journal Article)

Chemical References

• Vitamin E
• Glutens

Topics

• Aged
• Celiac Disease (complications, diet therapy, pathology)
• Glutens (adverse effects)
• Humans
• Male
• Myositis (complications, diet therapy, pathology)
• Myositis, Inclusion Body (complications, diet therapy, pathology)
• Vitamin E (administration & dosage)
• Vitamin E Deficiency (complications, diet therapy, pathology)