Abstract | BACKGROUND: OBJECTIVE: METHODS: RESULTS: Compared with lesion-free specimens, hamartomas exhibited decreased levels of TIMPs and messenger RNA expression of TIMP-1, and increased content of MMP-1 and MMP-13 and activity of MMP-9, although gelatinase gene expression was diminished. Gene expression of MMP-15 and MMP-17 was not affected but was diminished for MMP-14. CONCLUSION: The significant variations of the above extracellular matrix molecules between lesion-free specimens and tuberous sclerosis complex hamartomas overall favors a collagenous protein-degrading microenvironment in affected skin, and argue in support of antiprotease treatment for disfiguring skin lesions.
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Authors | Eleni Papakonstantinou, Alexander Dionyssopoulos, Alexios J Aletras, Chrisanthi Pesintzaki, Aristippos Minas, George Karakiulakis |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 51
Issue 4
Pg. 526-33
(Oct 2004)
ISSN: 1097-6787 [Electronic] United States |
PMID | 15389186
(Publication Type: Journal Article)
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Chemical References |
- Matrix Metalloproteinase Inhibitors
- Tissue Extracts
- Tissue Inhibitor of Metalloproteinase-1
- Tissue Inhibitor of Metalloproteinases
- Tissue Inhibitor of Metalloproteinase-2
- Collagenases
- Gelatinases
- MMP13 protein, human
- Matrix Metalloproteinase 13
- Matrix Metalloproteinases
- Matrix Metalloproteinases, Membrane-Associated
- Metalloendopeptidases
- Matrix Metalloproteinase 9
- Matrix Metalloproteinase 1
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Topics |
- Adult
- Collagenases
(metabolism)
- Gelatinases
(metabolism)
- Gene Expression
- Humans
- Male
- Matrix Metalloproteinase 1
(metabolism)
- Matrix Metalloproteinase 13
- Matrix Metalloproteinase 9
(metabolism)
- Matrix Metalloproteinase Inhibitors
- Matrix Metalloproteinases
(genetics, metabolism)
- Matrix Metalloproteinases, Membrane-Associated
- Metalloendopeptidases
(metabolism)
- Skin
(enzymology)
- Tissue Extracts
(metabolism)
- Tissue Inhibitor of Metalloproteinase-1
(metabolism)
- Tissue Inhibitor of Metalloproteinase-2
(metabolism)
- Tissue Inhibitor of Metalloproteinases
(genetics, metabolism)
- Tuberous Sclerosis
(enzymology, metabolism, surgery)
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