Chemical constituents of Glycosmis arborea: three new carbazole alkaloids and their biological activity.

Abstract

As part of the phytochemical studies of the plant genus Glycosmis, the constituents of the plant Glycosmis arborea were investigated. Three new carbazole alkaloids named glybomines A (1), B (2), and C (3), along with known monomeric alkaloids belonging to the carbazole, quinazoline, furoquinoline, quinolone, and acridone classes, were isolated from stems of the plant collected at Mymensing in Dhaka, Bangladesh. Glybomine A (1) is the first example of a 2,5-oxygenated carbazole alkaloid from natural sources. As a primary screening test for anti-tumor promoters, nine alkaloids isolated from this plant have been tested for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) induction by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). All alkaloids tested showed inhibitory activity.

• Authors: Chihiro Ito, Masataka Itoigawa, Atsuko Sato, Choudhury M Hasan, Mohammad A Rashid, Harukuni Tokuda, Teruo Mukainaka, Hoyoku Nishino, Hiroshi Furukawa
• Journal: Journal of natural products (J Nat Prod) Vol. 67 Issue 9 Pg. 1488-91 (Sep 2004) ISSN: 0163-3864 [Print] United States
• PMID: 15387647 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Alkaloids
• Antigens, Viral
• Carbazoles
• Epstein-Barr virus early antigen
• glybomine A
• glybomine B
• glybomine C
• Tetradecanoylphorbol Acetate

Topics

• Alkaloids (chemistry, isolation & purification, pharmacology)
• Antigens, Viral (drug effects)
• Bangladesh
• Carbazoles (chemistry, isolation & purification, pharmacology)
• Molecular Structure
• Nuclear Magnetic Resonance, Biomolecular
• Plants, Medicinal (chemistry)
• Rutaceae (chemistry)
• Tetradecanoylphorbol Acetate (pharmacology)