Cobalt radiation with or without low-dose cisplatin for treatment of canine naso-sinus carcinomas.

Abstract

The objective of this study was to determine if low-dose cisplatin could be added safely to radiation therapy for the treatment of naso-sinus carcinomas in dogs. Thirty-one dogs were evaluated; 18 of these dogs received cobalt radiation in combination with low-dose cisplatin while 13 dogs received radiation alone. No difference was observed for acute or late radiation effects. Cisplatin was administered at a dosage of 7.5 mg/m2 20 min prior to every other radiation treatment. An initial dose of 10 mg/m2 was intended but toxicity (primarily azotemia) was unacceptable. Cisplatin was administered as prescribed in 12 of 18 dogs. Cisplatin was discontinued in 2 dogs because of azotemia. In the other 4 dogs cisplatin was not administered as prescribed because the dogs were withdrawn from treatment due to disease progression or radiation effects. There was no long-term renal disease in patients who developed azotemia. The overall median survival was 433 days with 4 (12.9%) dogs still alive at the completion of the study.

• Authors: Marie-Eve Nadeau, Barbara E Kitchell, Robert L Rooks, Susan M LaRue
• Journal: Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association (Vet Radiol Ultrasound) 2004 Jul-Aug Vol. 45 Issue 4 Pg. 362-7 ISSN: 1058-8183 [Print] England
• PMID: 15373266 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Cisplatin

Topics

• Animals
• Antineoplastic Agents (administration & dosage)
• California (epidemiology)
• Cisplatin (administration & dosage)
• Combined Modality Therapy (veterinary)
• Dog Diseases (drug therapy, mortality, pathology, radiotherapy)
• Dogs
• Drug Administration Schedule
• Female
• Male
• Nasopharyngeal Neoplasms (drug therapy, radiotherapy, veterinary)
• Neoplasm Staging
• Records (veterinary)
• Retrospective Studies
• Survival Analysis