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Blood transfusions in the therapy of a case of prolidase deficiency.

Abstract
A case is reported of a 15-year-old boy with prolidase deficiency and marked urinary excretion of the iminodipeptide gly-pro. Prolidase activity of erythrocytes against substrate glycyl-proline was deficient, but after blood transfusions this was increased to 15.7% of donor activity and declined to 12% and 3.4% of normal activity after 8 and 45 days, respectively. Urinary iminodipeptide levels following transfusion remained unaltered.
AuthorsE Berardesca, D Fideli, M Bellosta, K M Dyne, G Zanaboni, G Cetta
JournalThe British journal of dermatology (Br J Dermatol) Vol. 126 Issue 2 Pg. 193-5 (Feb 1992) ISSN: 0007-0963 [Print] England
PMID1536787 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Dipeptides
  • glycylproline
  • Dipeptidases
  • proline dipeptidase
Topics
  • Adolescent
  • Blood Component Transfusion
  • Dipeptidases (deficiency)
  • Dipeptides (urine)
  • Foot Ulcer (etiology, therapy)
  • Humans
  • Male

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