Experimental renal papillary necrosis in the rat: the selective vulnerability of medullary structures to injury.

Abstract

Acute renal papillary necrosis was produced in rats by the administration of ethyleneimine. Low doses resulted in necrosis of interstitial cells, thin limbs of the loops of Henle and vasa recta, while collecting ducts were spared (subtotal renal papillary necrosis). High doses resulted in necrosis of all elements of the papilla (total renal papillary necrosis). Athough the ranges of the doses that produced these two patterns of necrosis overlapped, it is clear that there is a dose dependent selective vulnerability or renal medullary structures to injury by the toxic agent studied.

• Authors: R A Axelsen
• Journal: Virchows Archiv. A, Pathological anatomy and histology (Virchows Arch A Pathol Anat Histol) Vol. 381 Issue 1 Pg. 79-84 (Dec 12 1978) ISSN: 0340-1227 [Print] Germany
• PMID: 153648 (Publication Type: Journal Article)

Chemical References

• Aziridines

Topics

• Animals
• Aziridines
• Dose-Response Relationship, Drug
• Female
• Kidney Papillary Necrosis (chemically induced, pathology)
• Kidney Tubules (pathology)
• Loop of Henle (pathology)
• Necrosis
• Rats