Abstract | BACKGROUND:
Diabetes mellitus is one of the most common endocrine diseases and affects most body organs. It affects gastric acid secretion, but this effect has not been fully understood. As the effects of diabetes on gastric pepsin secretion has not been proved yet, in this experimental study basal and distension-stimulated acid and pepsin secretions of diabetic and non-diabetic rats have been compared. MATERIAL AND METHODS: RESULTS: Basal gastric secretions were similar in diabetic and non-diabetic animals. Distention-stimulated acid secretions in diabetic and non-diabetic rats were 3.24 +/- 0.16 and 8.05 +/- 0.21 micromol/15 min, respectively, which were significantly different (P = 0.00001). Distention-induced pepsin secretion in diabetic and non diabetic rats were 3.16 +/- 0.13 and 5.24 +/- 0.16 microg/15min, respectively, which were significantly different (P = 0.00001). CONCLUSION: In this study the stomach of diabetic animals showed less reaction to distention, which may be due to the reduction of acid and pepsin secretary cells, reduction of the function of the cells, gastric atrophy or gastric vagus neuropathy. These probabilities need to be examined.
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Authors | Fatemeh Nabavizadeh Rafsanjani, Jalal Vahedian |
Journal | Diabetes research and clinical practice
(Diabetes Res Clin Pract)
Vol. 66
Issue 1
Pg. 1-6
(Oct 2004)
ISSN: 0168-8227 [Print] Ireland |
PMID | 15364155
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Blood Glucose
(metabolism)
- Body Weight
- Diabetes Mellitus, Type 1
(blood, enzymology, physiopathology)
- Female
- Gastric Mucosa
(metabolism)
- Laparotomy
- Organ Size
- Pepsin A
(metabolism)
- Rats
- Rats, Inbred Strains
- Reference Values
- Stomach
(anatomy & histology, enzymology, physiopathology)
- Tracheostomy
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