Adipose tissue expression of IL-18 and HIV-associated lipodystrophy.

Abstract

IL-18 is an inducer of apoptosis/tissue injury. IL-18 messenger RNA expression was examined in adipose tissue (AT) obtained from HIV patients with lipodystrophy, without lipodystrophy and healthy controls. IL-18 mRNA was expressed in AT at increased levels in lipodystrophy-positive compared with lipodystrophy-negative patients and healthy controls. Higher levels of IL-18 mRNA were found in femoral-gluteal AT compared with abdominal AT, and correlated with limb fat loss. These findings suggest that IL-18 is linked to HIV-associated lipodystrophy.

• Authors: Birgitte Lindegaard, Ann-Brit Eg Hansen, Henriette Pilegaard, Pernille Keller, Jan Gerstoft, Bente Klarlund Pedersen
• Journal: AIDS (London, England) (AIDS) Vol. 18 Issue 14 Pg. 1956-8 (Sep 24 2004) ISSN: 0269-9370 [Print] England
• PMID: 15353983 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-18
• RNA, Messenger
• Tumor Necrosis Factor-alpha

Topics

• Adipose Tissue (metabolism)
• Analysis of Variance
• Cross-Sectional Studies
• HIV-Associated Lipodystrophy Syndrome (metabolism)
• Humans
• Interleukin-18 (metabolism)
• RNA, Messenger (metabolism)
• Tumor Necrosis Factor-alpha (metabolism)