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Distribution of adhesion molecules, IgE, and CD23 in a case of angiolymphoid hyperplasia with eosinophilia.

Abstract
Angiolymphoid hyperplasia with eosinophilia developed in a 13-year-old boy. The immune phenotype of infiltrating cells and the distribution of adhesion molecules of the integrin, immunoglobulin, and selectin families were analyzed with monoclonal antibodies. The infiltrate consisted mainly of helper lymphocytes, monocytes, eosinophils, CD1+ dendritic cells, and mast cells. A CD23/Fc epsilon receptor was present on 40% of these cells, and surface bound IgE was present on 30% of these cells. The latter was found on all cell types. A cellular adhesion molecule analysis revealed that the proliferating endothelial cells were expressing constitutive ICAM-1, LFA-3, VLA-1, VLA-3, VLA-5, alpha 6, and beta 3-integrin chain as well as activation-dependent VLA-2, VCAM-1, and human lymphocyte antigen-DR. The infiltrating cells expressed LFA-1 and CD2, the correlating ligands for ICAM-1 and LFA-3. Our studies support previous observations of an unusual IgE-mediated immune reaction, and suggest an additional pathogenic role for adhesion events in the development of the pathognomonic cellular composition in angiolymphoid hyperplasia with eosinophilia.
AuthorsP von den Driesch, M Gruschwitz, H Schell, W Sterry
JournalJournal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 26 Issue 5 Pt 2 Pg. 799-804 (May 1992) ISSN: 0190-9622 [Print] United States
PMID1535350 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Antigens, Differentiation, B-Lymphocyte
  • Cell Adhesion Molecules
  • Receptors, Fc
  • Receptors, IgE
  • Immunoglobulin E
Topics
  • Adolescent
  • Angiolymphoid Hyperplasia with Eosinophilia (blood, diagnosis, immunology, pathology)
  • Antigens, Differentiation, B-Lymphocyte (analysis, immunology)
  • Cell Adhesion Molecules (analysis, immunology)
  • Dendritic Cells (immunology, pathology)
  • Facial Neoplasms (blood, diagnosis, immunology, pathology)
  • Female
  • Humans
  • Immunoglobulin E (analysis, immunology)
  • Immunohistochemistry
  • Leukocytes (immunology, pathology)
  • Male
  • Mast Cells (immunology, pathology)
  • Middle Aged
  • Receptors, Fc (analysis, immunology)
  • Receptors, IgE
  • Skin (blood supply, immunology, pathology)
  • Skin Neoplasms (blood, diagnosis, immunology, pathology)

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