Zolpidem for postanoxic spasticity.

A 28-year-old male sustained anoxic brain damage following aborted cardiac arrest, and subsequently developed severe muscular rigidity and spasticity involving all extremities. The spasticity was refractory to the standard regimens used for spastic hypertonia. Zolpidem dramatically inhibited muscular rigidity, spasticity, and dystonic posturing in a dose-dependent manner, resulting in a sustained improvement of his global performance over four years. The authors postulate a central mechanism of action by selective inhibition of GABAergic inhibitory neurons, and suggest a controlled clinical study to investigate the potential efficacy of zolpidem in relieving spasticity related to postanoxic brain injury.
AuthorsFarhad F Shadan, J Steven Poceta, Lawrence E Kline
JournalSouthern medical journal (South Med J) Vol. 97 Issue 8 Pg. 791-2 (Aug 2004) ISSN: 0038-4348 [Print] United States
PMID15352681 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • GABA Agonists
  • Pyridines
  • zolpidem
  • Adult
  • GABA Agonists (therapeutic use)
  • Heart Arrest (complications)
  • Humans
  • Male
  • Muscle Spasticity (drug therapy, etiology)
  • Pyridines (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: