Abstract |
Smith-Magenis syndrome (SMS) is a multiple congenital anomaly syndrome characterized by an interstitial deletion of chromosome 17p11.2. Sleep problems such as nocturnal awakening and abnormality in the percentage of rapid eye movement (REM) sleep are frequently observed in patients with SMS, and several medications have been administered to improve the sleep disorders. Here we present a female case of SMS showing early waking and reduction of REM sleep, which were corrected by human growth hormone (GH) replacement for her dwarfism. Also, we report changes in the sleep-wakefulness circadian rhythm and polysomnographical data before and after the start of human GH replacement. It is speculated that GH deficiency could be involved in sleep disturbance in SMS.
|
Authors | Masahiro Itoh, Masaharu Hayashi, Takeshi Hasegawa, Masayuki Shimohira, Jun Kohyama |
Journal | Brain & development
(Brain Dev)
Vol. 26
Issue 7
Pg. 484-6
(Oct 2004)
ISSN: 0387-7604 [Print] Netherlands |
PMID | 15351087
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
|
Topics |
- Abnormalities, Multiple
(drug therapy, genetics, physiopathology)
- Child, Preschool
- Chromosome Deletion
- Chromosome Disorders
(drug therapy, genetics, physiopathology)
- Chromosomes, Human, Pair 17
(genetics)
- Dwarfism, Pituitary
(drug therapy, genetics, physiopathology)
- Female
- Growth Hormone
(administration & dosage, deficiency)
- Humans
- Injections, Subcutaneous
- Sleep Disorders, Circadian Rhythm
(drug therapy, genetics, physiopathology)
- Sleep Wake Disorders
(drug therapy, genetics, physiopathology)
- Sleep, REM
(drug effects, genetics)
- Syndrome
- Treatment Outcome
|