Abstract | BACKGROUND: METHODS: 20 IgA patients aged 36.5 +/- 10.77 with creatinine clearance (Cr(cl)) 105.71 +/- 27.3 ml/min and proteinuria 3.31 +/- 2.01 g/24 h were given orally 810 mg EPA and 540 mg DHA daily for 12 months. Before and at the end of the study, 24-hour proteinuria, serum homocysteine, and Cr(cl) were measured. At the same time, renal vascular function was estimated as dopamine-induced glomerular filtration response (DIR). DIR was measured as: two 120-min lasting Cr(cl) (before and during 2 microg/kg b.w./min i.v. dopamine). RESULTS: The results obtained during follow-up were as follows (baseline vs. after therapy): DIR 14.9 +/- 16.4 vs. 30.3 +/- 14.3% (p < 0.01); urine protein 2.31 +/- 2.01 vs. 1.31 +/- 1.37 g/24 h (p < 0.01); (Cr(cl)) 105.71 +/- 27.3 vs. 103.9 +/- 20.9 ml/min (n.s.); NAG 8.3 +/- 1.8 vs. 6.0 +/- 1.2 U/g(creat) (p < 0.01), and homocysteine 16.2 +/- 3.15 vs. 13.8 +/- 2.6 micromol/l (p < 0.05). The only correlation found was linear correlation between basal DIR and DIR change (r = -0.570; p < 0.010) and basal NAG (r = -0.460; p < 0.50). CONCLUSIONS: Omega-3 supplementation is associated with the improvement of both renal vascular function and tubule function.
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Authors | Beata Sulikowska, Tomasz Niewegłowski, Jacek Manitius, Wiesława Lysiak-Szydłowska, Bolesław Rutkowski |
Journal | American journal of nephrology
(Am J Nephrol)
2004 Sep-Oct
Vol. 24
Issue 5
Pg. 474-82
ISSN: 0250-8095 [Print] Switzerland |
PMID | 15340256
(Publication Type: Clinical Trial, Journal Article)
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Copyright | 2004 S. Karger AG, Basel |
Chemical References |
- Fatty Acids, Omega-3
- Dopamine
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Topics |
- Adolescent
- Adult
- Dopamine
- Fatty Acids, Omega-3
(administration & dosage, pharmacology)
- Female
- Glomerular Filtration Rate
(drug effects)
- Glomerulonephritis, IGA
(drug therapy, physiopathology)
- Humans
- Male
- Middle Aged
- Time Factors
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