Ciclopirox (Loprox) gel for superficial fungal infections.

Abstract

Ciclopirox (Loprox) is a broad-spectrum antifungal medication that also has antibacterial and anti-inflammatory properties. Its main mode of action is thought to be its high affinity for trivalent cations, which inhibit essential co-factors in enzymes. Clinical trials have shown that ciclopirox gel is a successful treatment for seborrheic dermatitis of the scalp as well as for tinea pedis. Adverse effects are generally mild and include a skin-burning sensation, contact dermatitis, and pruritus. Ciclopirox is indicated in the US for the treatment of tinea pedis, tinea corporis, pityriasis versicolor, seborrheic dermatitis, and cutaneous candidiasis.

• Authors: A K Gupta, R Bluhm
• Journal: Skin therapy letter (Skin Therapy Lett) 2004 Aug-Sep Vol. 9 Issue 7 Pg. 4-5, 9 ISSN: 1201-5989 [Print] Canada
• PMID: 15334276 (Publication Type: Journal Article, Review)

Chemical References

• Antifungal Agents
• Gels
• Pyridones
• Ciclopirox

Topics

• Administration, Topical
• Antifungal Agents (therapeutic use)
• Canada
• Ciclopirox
• Dermatomycoses (diagnosis, drug therapy)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Female
• Gels
• Humans
• Male
• Prognosis
• Pyridones (therapeutic use)
• Randomized Controlled Trials as Topic
• Severity of Illness Index
• Treatment Outcome