Abstract | OBJECTIVE: BACKGROUND: METHODS: The pretreatment amplitude of the compound muscle action potential (CMAP) was obtained in 10 patients with a migraine frequency of two to six attacks per month following stimulation of the temporal branch of the facial nerve. Patients were subsequently injected with 20 units of botulinum toxin type A at predefined sites in the procerus and corrugator muscles. CMAP was obtained on days 7, 30, 60, and 90 after injection. Migraine frequency, as reported in headache diaries, was compared with the amplitudes obtained. RESULTS: A 50% decrease in CMAP was demonstrated in the total group by day 7. Maximal decline of CMAP was observed by day 30, and was sustained at day 60. Migraine frequency declined by 50% or more in 7 of 10 patients by day 60. Migraine response to botulinum toxin type A treatment did not correlate with the denervation pattern. CONCLUSION:
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Authors | Johan A Smuts, Donovan Schultz, Adri Barnard |
Journal | Headache
(Headache)
Vol. 44
Issue 8
Pg. 801-5
(Sep 2004)
ISSN: 0017-8748 [Print] United States |
PMID | 15330827
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Neuromuscular Agents
- Botulinum Toxins, Type A
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Topics |
- Action Potentials
(drug effects)
- Botulinum Toxins, Type A
(pharmacology, therapeutic use)
- Facial Muscles
(drug effects)
- Humans
- Migraine Disorders
(physiopathology, prevention & control)
- Neuromuscular Agents
(pharmacology, therapeutic use)
- Pilot Projects
- Prospective Studies
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