The discrepancy between electrophoretic and nephelometric determinations of serum gamma-globulin level.

Abstract

We studied the significance of discrepancies in correlation between serum gamma-globulin levels electrophoretically estimated and immunoglobulin levels nephelometrically determined. Discrepancies appeared in cases with IgA myeloma, macroglobulinemia, and rare types of dysgammaglobulinemia frequently overlooked in serum electrophoresis, IgD myeloma and gamma-heavy chain disease. It is suggested that comparison of the gamma-globulin levels by the different methods is a simple and useful method of detecting these dysgammaglobulinemias.

• Authors: Keiko Morita, Yasuyuki Okamoto
• Journal: Clinical laboratory (Clin Lab) Vol. 50 Issue 7-8 Pg. 415-8 ( 2004) ISSN: 1433-6510 [Print] Germany
• PMID: 15330509 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Immunoglobulins
• Myeloma Proteins
• gamma-Globulins
• myeloma immunoglobulins

Topics

• Dysgammaglobulinemia (diagnosis)
• Electrophoresis, Cellulose Acetate (methods)
• Humans
• Immunoglobulins (blood)
• Myeloma Proteins
• Nephelometry and Turbidimetry (methods)
• Reproducibility of Results
• Waldenstrom Macroglobulinemia (diagnosis)
• gamma-Globulins (analysis)