Abstract | BACKGROUND: MATERIALS AND METHODS: The levels of DPD in cancer cells, stromal cells and normal glands were measured immunohistochemically in 111 patients with T3 gastric carcinoma. Adjuvant chemotherapy with oral UFT ( uracil/ tegafur[4:1]) was administered to 95 patients for more than 1 year after surgery. RESULTS: Forty-two (37.8%) patients demonstrated high DPD expression in the cytoplasm of their cancer cells. In patients with low DPD expression in cancer cells, the 5-year survival rates were 64.5% in patients given FU and 42.8% in those not given FU (p=0.014). Neither stromal cells nor normal glands affected the efficacy of FU treatment in relation to their DPD expression. CONCLUSION: DPD expression in cancer cells but not in stromal cells could be a predictor of the efficacy of FU chemotherapy in patients with T3 gastric carcinoma.
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Authors | Kazunori Hisamitsu, Shunichi Tsujitani, Kenichi Yamaguchi, Kenji Fukuda, Ichiro Konishi, Nobuaki Kaibara |
Journal | Anticancer research
(Anticancer Res)
2004 Jul-Aug
Vol. 24
Issue 4
Pg. 2495-501
ISSN: 0250-7005 [Print] Greece |
PMID | 15330204
(Publication Type: Journal Article)
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Chemical References |
- Antimetabolites, Antineoplastic
- Tegafur
- Uracil
- Dihydrouracil Dehydrogenase (NADP)
- Thymidylate Synthase
- Fluorouracil
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Topics |
- Adenocarcinoma
(drug therapy, enzymology, pathology, surgery)
- Antimetabolites, Antineoplastic
(therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, pharmacokinetics)
- Chemotherapy, Adjuvant
- Dihydrouracil Dehydrogenase (NADP)
(biosynthesis, metabolism)
- Female
- Fluorouracil
(pharmacokinetics, therapeutic use)
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Neoplasm Staging
- Stomach Neoplasms
(drug therapy, enzymology, pathology, surgery)
- Stromal Cells
(enzymology)
- Tegafur
(administration & dosage, pharmacokinetics)
- Thymidylate Synthase
(biosynthesis)
- Uracil
(administration & dosage, pharmacokinetics)
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