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Magnesium treatment for sudden hearing loss.

Abstract
Magnesium treatment has been repeatedly shown to reduce the incidence of both temporary and permanent noise-induced hearing loss. We hypothesized that it might also improve the permanent threshold shift in patients with acute-onset hearing loss. In a prospective, randomized, double-blind, placebo-controlled trial, 28 patients with idiopathic sudden sensorineural hearing loss were treated with either steroids and oral magnesium (study group) or steroids and a placebo (control group). Compared to the controls, the magnesium-treated group had a significantly higher proportion of patients with improved hearing (>10 dB hearing level) across all frequencies tested, and a significantly greater mean improvement in all frequencies. Analysis of the individual data confirmed that more patients treated with magnesium experienced hearing improvement, and at a larger magnitude, than control subjects. Magnesium is a relatively safe and convenient adjunct to steroid treatment for enhancing the improvement in hearing, especially in the low-tone range, in patients with sudden sensorineural hearing loss.
AuthorsBen I Nageris, David Ulanovski, Joseph Attias
JournalThe Annals of otology, rhinology, and laryngology (Ann Otol Rhinol Laryngol) Vol. 113 Issue 8 Pg. 672-5 (Aug 2004) ISSN: 0003-4894 [Print] United States
PMID15330150 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Magnesium
Topics
  • Adult
  • Aged
  • Double-Blind Method
  • Female
  • Hearing Loss, Sudden (drug therapy)
  • Humans
  • Magnesium (therapeutic use)
  • Male
  • Middle Aged
  • Prospective Studies

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