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Efficacy of mycophenolate mofetil in patients with chronic immune demyelinating polyneuropathy.

Abstract
The authors retrospectively reviewed the efficacy of mycophenolate mofetil (MMF; mean dose, 2 g/day given for an average of 14 months) in 21 patients with immune demyelinating polyneuropathy. There were no significant differences in the median strength, sensory, or Rankin scores before and after treatment. In patients with immunoglobulin (Ig) M neuropathy, the M-protein decreased by 22%. Three patients with chronic inflammatory demyelinating polyneuropathy (30%) and one patient with IgM neuropathy (13%) improved. The authors found that MMF induced a modest benefit in ~20% of their patients and stabilized patient condition, allowing reduction of steroid or IVIg therapy.
AuthorsKenneth C Gorson, Anthony A Amato, Allan H Ropper
JournalNeurology (Neurology) Vol. 63 Issue 4 Pg. 715-7 (Aug 24 2004) ISSN: 1526-632X [Electronic] United States
PMID15326250 (Publication Type: Journal Article, Review)
Chemical References
  • Adrenal Cortex Hormones
  • Immunoglobulin M
  • Immunoglobulins, Intravenous
  • Immunosuppressive Agents
  • Mycophenolic Acid
Topics
  • Adrenal Cortex Hormones (therapeutic use)
  • Adult
  • Aged
  • Combined Modality Therapy
  • Drug Evaluation
  • Female
  • Humans
  • Immunoglobulin M (analysis)
  • Immunoglobulins, Intravenous
  • Immunosuppressive Agents (adverse effects, therapeutic use)
  • Lymphocyte Activation (drug effects)
  • Male
  • Middle Aged
  • Mycophenolic Acid (adverse effects, analogs & derivatives, therapeutic use)
  • Nausea (chemically induced)
  • Neurologic Examination
  • Paraproteinemias (drug therapy, immunology)
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (drug therapy, immunology)
  • Retrospective Studies
  • Treatment Outcome

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