Abstract | BACKGROUND: METHODS: Sixty-five patients were randomized to strength training of elbow flexors and ankle dorsiflexors or non-training. After 26 weeks albuterol (sustained-release, 8 mg BID) was added in a randomized, double-blind, placebo-controlled design. Primary outcome was maximum voluntary isometric strength (MVIC) at 52 weeks. Secondary outcomes comprised dynamic strength and muscle volume. RESULTS: Training and albuterol were well tolerated. Training of elbow flexors did not result in a significant effect on MVIC, but dynamic strength improved significantly. Elbow flexor MVIC strength increased significantly in albuterol vs placebo treated patients. Ankle dorsiflexor strength decreased in all groups. Eleven out of twelve non-trained muscles in the albuterol group showed a positive effect on MVIC compared to the placebo group (p < 0.05 in seven muscle groups). Muscle volume decreased in the placebo-treated, and increased in the albuterol-treated patients. No synergistic or antagonistic effects were observed between training and albuterol. CONCLUSIONS: In FSHD strength training and albuterol appear safe interventions with limited positive effect on muscle strength and volume. Consequences of prolonged use are presently unclear, which precludes routine prescription.
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Authors | E L van der Kooi, O J M Vogels, R J G P van Asseldonk, E Lindeman, J C M Hendriks, M Wohlgemuth, S M van der Maarel, G W Padberg |
Journal | Neurology
(Neurology)
Vol. 63
Issue 4
Pg. 702-8
(Aug 24 2004)
ISSN: 1526-632X [Electronic] United States |
PMID | 15326246
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenergic beta-Agonists
- Delayed-Action Preparations
- Albuterol
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Topics |
- Adrenergic beta-Agonists
(administration & dosage, therapeutic use)
- Adult
- Albuterol
(administration & dosage, therapeutic use)
- Ankle Joint
- Combined Modality Therapy
- Delayed-Action Preparations
- Double-Blind Method
- Elbow Joint
- Female
- Humans
- Male
- Middle Aged
- Muscular Dystrophy, Facioscapulohumeral
(drug therapy, therapy)
- Physical Endurance
- Respiratory Function Tests
- Treatment Outcome
- Weight Lifting
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