Novel fluoro- and hydroxyl-containing jasmonate derivatives as highly efficient elicitors in suspension cultures of Taxus chinensis.

To develop more effective abiotic elicitors for cell suspension cultures of T. chinensis to meet the needs for paclitaxel as anti-tumor drug, some fluoro- or hydroxyl-containing groups are introduced to the ester moiety of jasmonic acid by the esterification or acylation with bis(trichloromethyl) carbonate and corresponding alcohol. Some of them are found to be novel and effective elicitors, which can enhance the production of taxuyunnanine C (Tc) up to 60% more than that by methyl jasmonate (MJA) in T. chinensis cell cultures.
AuthorsZhenjiang Zhao, Yufang Xu, Zhigang Qian, Wenhong Tian, Xuhong Qian, Jian-Jiang Zhong
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 14 Issue 18 Pg. 4755-8 (Sep 20 2004) ISSN: 0960-894X [Print] England
PMID15324902 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • 2,3-dihydroxypropyl jasmonate
  • Cyclopentanes
  • Esters
  • Hydrocarbons, Fluorinated
  • Oxylipins
  • Taxoids
  • pentafluoropropyl jasmonate
  • taxuyunnanine C
  • jasmonic acid
  • Acylation
  • Cells, Cultured
  • Cyclopentanes (chemical synthesis, chemistry, pharmacology)
  • Esterification
  • Esters (chemical synthesis, chemistry, pharmacology)
  • Hydrocarbons, Fluorinated (chemical synthesis, chemistry, pharmacology)
  • Oxylipins
  • Stereoisomerism
  • Structure-Activity Relationship
  • Taxoids (metabolism)
  • Taxus (drug effects, growth & development, metabolism)
  • Time Factors

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