Abstract |
We present a review of the literature concerning treatment of psoriasis with humanized monoclonal antibody (hu 1124, efaluzimab, Xanelin) against the CD11a component of lymphocyte-function-associated antigen-1 (LFA-1). Efaluzimab inhibits the interaction of CD11a (LFA-1) with various ICAM molecules. Because ICAM-1 (CD54) is expressed on activated endothelial cells and antigen presenting cells (APCs), the antibody inhibits both the APC-T cell interaction and the T- cell adhesion to endothelial cells, their subsequent activation, which results in decreasing of transendothelial migration. Treatment with Efaluzimab was well tolerated and the majority adverse events were dose-related. Adverse events were described as mild at doses of 0.3 mg/kg or less and included mild chills, abdominal discomfort, headache, and fever (flu-like complaints), apart from this white blood cell counts and lymphocyte counts transient increase were observed. Headache was the most common dose-limiting toxicity observed at a single dose of 0.6 mg/kg or higher.
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Authors | Aldona Pietrzak, Monika Podhorecka, Grazyna Chodorowska, Jacek Roliński, Janusz Urban |
Journal | Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina
(Ann Univ Mariae Curie Sklodowska Med)
Vol. 58
Issue 2
Pg. 174-8
( 2003)
ISSN: 0066-2240 [Print] Poland |
PMID | 15323188
(Publication Type: Journal Article, Review)
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Chemical References |
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Humanized
- CD11 Antigens
- Intercellular Adhesion Molecule-1
- efalizumab
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Topics |
- Antibodies, Monoclonal
(adverse effects, therapeutic use)
- Antibodies, Monoclonal, Humanized
- CD11 Antigens
(drug effects)
- Humans
- Intercellular Adhesion Molecule-1
(drug effects)
- Psoriasis
(drug therapy)
- T-Lymphocytes
(metabolism)
- Treatment Outcome
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