Abstract | BACKGROUND:
Ectopic pregnancy is the implantation of fertilized ovum on any tissue other than the endometrial lining of the uterus. OBJECTIVE: MATERIALS AND METHODS: From January 2000 to October 2002 five patients were diagnosed with unruptured ectopic pregnancy in Hospital Juarez de Mexico. The inclusion criteria were: hemodynamic stability, gestational sac of < 40 mm, serum beta-hCG concentration < 15,000 mIU/L and future fertility desire. Systemic methotrexate was administered as an intramuscular injection of 50 mg. Evaluation was based on transvaginal ultrasonography, beta-hCG levels and hysterosalpingography. RESULTS: Five patients with unruptured ectopic pregnancy were treated with methotrexate. Successful rate, after one or two injections, was 100% (5 patients). The size of ectopic pregnancy as estimated by ultrasonographic was 33.33 mm. Negligible plasma beta-hCG values were reached 45.6 +/- 19.85 days after the time of treatment. Ultrasonographic scanning demonstrated progressive disorganization and the gestational sac disappeared at 134 days after treatment. There were no adverse effects from the chemotherapy. In 3 of 4 women who underwent hysterosalpingography following treatment, patency of the affected tube was observed. Three women experienced an intrauterine pregnancy spontaneously in the methotrexate group. CONCLUSIONS:
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Authors | Elizabeth Rojas Mora, Luis Edmundo Hernández Vivar, Jesús Sánchez Contreras, Roberto José Risco Cortés, Victor Hugo Pulido Olivares |
Journal | Ginecologia y obstetricia de Mexico
(Ginecol Obstet Mex)
Vol. 72
Pg. 135-41
(Apr 2004)
ISSN: 0300-9041 [Print] Mexico |
Vernacular Title | Tratamiento médico del embarazo ectópico no roto. |
PMID | 15318753
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Abortifacient Agents, Nonsteroidal
- Chorionic Gonadotropin, beta Subunit, Human
- Methotrexate
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Topics |
- Abortifacient Agents, Nonsteroidal
(administration & dosage, adverse effects, therapeutic use)
- Adult
- Chorionic Gonadotropin, beta Subunit, Human
(blood)
- Female
- Humans
- Hysterosalpingography
- Injections, Intramuscular
- Methotrexate
(administration & dosage, adverse effects, therapeutic use)
- Pregnancy
- Pregnancy Trimester, First
- Pregnancy, Tubal
(blood, diagnostic imaging, drug therapy)
- Safety
- Treatment Outcome
- Ultrasonography
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