[Expression of thymidine phosphorylase in cancer].

Abstract

OBJECTIVE:

To study the thymidine phosphorylase (TP) expression in different types of cancer and its correlation with tumor microvessel density (MVD).

METHODS:

The expression of TP and MVD was detected by immunohistochemistry method. In a series of 251 cancer patients there were 48 patients with gastric cancer, 53 with colorectal cancer, 47 with breast cancer, 56 with cervical cancer, 47 with lung cancer. Normal gastric (n = 25), colorectal (n = 25), cervical (n = 17) and lung (n = 25) tissues around the cancer were also examined.

RESULTS:

The TP expression rate was 64.6% in gastric cancer, 67.9% in colorectal cancer, 80.9% in breast cancer, 82.1% in cervical cancer, and 63.8% in lung cancer, which was significantly higher than that in normal tissues (P = 0.0000). TP expression was positively correlated with MVD in gastric, colorectal, breast, and cervical cancers. The correlation was not statistically significant in lung cancer.

CONCLUSION:

This study indicates that TP overexpression in cancer may be associated with tumor angiogenesis.

• Authors: Li-na Jiang, Shi-ying Yu, Hui-hua Xiong, Meng-xian Zhang
• Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] (Zhonghua Zhong Liu Za Zhi) Vol. 26 Issue 5 Pg. 297-9 (May 2004) ISSN: 0253-3766 [Print] China
• PMID: 15312368 (Publication Type: English Abstract, Journal Article)

Chemical References

• Thymidine Phosphorylase

Topics

• Adult
• Aged
• Aged, 80 and over
• Breast Neoplasms (blood supply, enzymology)
• Colorectal Neoplasms (blood supply, enzymology)
• Female
• Humans
• Male
• Middle Aged
• Neovascularization, Pathologic (pathology)
• Stomach Neoplasms (blood supply, enzymology)
• Thymidine Phosphorylase (metabolism)
• Uterine Cervical Neoplasms (blood supply, enzymology)