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[Inhibitory effect of tumor suppressor PTEN on cell growth of endometrial carcinoma].

AbstractOBJECTIVE:
To evaluate the inhibitory effect of tumor suppressor PTEN on cell growth of endometrial carcinoma.
METHODS:
The exogenous wild PTEN cDNA via an adenoviral vector (Ad-PTEN) was introduced into Ishikawa cells. The expression of PTEN protein was detected by Western blot. The growth of Ishikawa cells was evaluated by trypan blue exclusion method and MTT.
RESULTS:
The expression of PTEN protein was induced on day 1, and greatly increasing on day 3 - 5 after Ad-PTEN infection. The expression of PTEN significantly inhibited the growth of Ishikawa cells, and also significantly inhibited the growth of Ishikawa cells induced by IGF-II.
CONCLUSION:
Adenovirus-mediated introduction of exogenous PTEN into human endometrial carcinoma cells can induce growth suppression. PTEN gene may be a novel therapeutic agent for endometrial carcinoma.
AuthorsXiao-yun Wan, Yi-fu Shi, Juan-qing Li
JournalZhonghua zhong liu za zhi [Chinese journal of oncology] (Zhonghua Zhong Liu Za Zhi) Vol. 26 Issue 5 Pg. 275-8 (May 2004) ISSN: 0253-3766 [Print] China
PMID15312361 (Publication Type: Journal Article)
Chemical References
  • Tumor Suppressor Proteins
  • Insulin-Like Growth Factor II
  • Phosphoric Monoester Hydrolases
  • PTEN Phosphohydrolase
  • PTEN protein, human
Topics
  • Adenoviridae (genetics)
  • Cell Proliferation
  • Endometrial Neoplasms (metabolism, pathology)
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Insulin-Like Growth Factor II (pharmacology)
  • PTEN Phosphohydrolase
  • Phosphoric Monoester Hydrolases (biosynthesis, genetics, physiology)
  • Recombination, Genetic
  • Transfection
  • Tumor Suppressor Proteins (biosynthesis, genetics, physiology)

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