Abstract | OBJECTIVE: METHOD: 222 patients were randomised in a double blind, multicentre study-156 (70%) had a painful knee joint and 66 (30%) a painful hip joint. The main efficacy criterion was pain intensity assessment after a single dose ( ibuprofen 400 mg, paracetamol 1000 mg). Functional disability assessment and patient global assessment were carried out over 14 days. RESULTS: The sum of the pain intensity difference over 6 hours after the first administration was significantly higher (p = 0.046) in the ibuprofen group than in the paracetamol group. Over 14 days pain intensity decreased from the first day and was significantly lower in the ibuprofen group than in the paracetamol group (p<0.05). The functional disability of the patient was assessed using the WOMAC; the ibuprofen group improved significantly over 2 weeks compared with the paracetamol group for each of the subscales: stiffness (p<0.002), pain (p<0.001), physical function (p<0.002). The drugs were equally safe. CONCLUSION: The IPSO study shows that for the treatment of osteoarthritic pain, ibuprofen 400 mg at a single and multiple dose (1200 mg/day) for 14 days is more effective than paracetamol, either as a single dose of 1000 mg or a multiple dose (3000 mg/day). Because ibuprofen and paracetamol have similar tolerability, this study indicates that the efficacy/tolerability ratio of ibuprofen is better than that of paracetamol in this indication over 14 days.
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Authors | F Boureau, H Schneid, N Zeghari, R Wall, P Bourgeois |
Journal | Annals of the rheumatic diseases
(Ann Rheum Dis)
Vol. 63
Issue 9
Pg. 1028-34
(Sep 2004)
ISSN: 0003-4967 [Print] England |
PMID | 15308513
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics, Non-Narcotic
- Acetaminophen
- Ibuprofen
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Topics |
- Acetaminophen
(adverse effects, therapeutic use)
- Aged
- Aged, 80 and over
- Analgesics, Non-Narcotic
(adverse effects, therapeutic use)
- Anthropometry
- Double-Blind Method
- Drug Administration Schedule
- Female
- Humans
- Ibuprofen
(adverse effects, therapeutic use)
- Male
- Middle Aged
- Osteoarthritis, Hip
(drug therapy)
- Osteoarthritis, Knee
(drug therapy)
- Pain Measurement
- Severity of Illness Index
- Treatment Outcome
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