[Importance of determination of proinflammatory cytokines in the blood of polytraumatized patients with sepsis].

Abstract

Severe sepsis and trauma complicated with multiple organ dysfunction syndrome (MODS) are among the leading causes of death in intensive therapy units, with mortality rate exceeding 50%. The outcome is not determined only by infection or trauma, but also by the intensity of immuno-inflammatory response, which is essential for host defence, but if uncontrolled leads to MODS. Pro-inflammatory cytokines (tumor necrosis factor-alpha--TNF-alpha, IL-1, IL-8, IL-12, IFN-gamma, etc.) represent a part of this immuno-inflammatory response to an insult. The results of the clinical investigation of correlation between pro-inflammatory cytokines (IL-8, IL-12, TNF-alpha, IFN-gamma), the outcome (survivors, non-survivors), and the severity (systemic inflammatory response syndrome--SIRS--less severe, and MODS--more severe) in polytraumatised patients with sepsis are presented in this paper. Mean values of IL-8 were 1.3-fold higher in non-survivors (p<0.05), and 60-fold higher in MODS group (p<0.01). Mean values of IL-12 were 1.6-fold higher in survivors (p<0.01), while the values between SIRS and MODS group did not differ significantly; mean values of TNF-alpha were 3-fold higher in survivors (p<0.05), and 46-fold higher in MODS group (p<0.01). Mean values of IFN-gamma did not differ significantly between the two groups regarding the outcome and severity. The obtained results indicated that IL-8 was a reliable predictor of lethal outcome and MODS (p<0.01), IL-12 a reliable predictor of survival (p<0.05), and TNF-alpha a reliable predictor of survival (p<0.05) and MODS (p<0.01).

• Authors: Maja Surbatović, Krsta Jovanović, Danilo Vojvodić, Nikola Filipović, Dragan Babić
• Journal: Vojnosanitetski pregled (Vojnosanit Pregl) 2004 Mar-Apr Vol. 61 Issue 2 Pg. 137-43 ISSN: 0042-8450 [Print] Serbia
• Vernacular Title: Znacaj odredivanja proinflamatornih citokina u serumu politraumatizovanih bolesnika sa sepsom.
• PMID: 15296118 (Publication Type: English Abstract, Journal Article)

Chemical References

• Biomarkers
• Cytokines
• Inflammation Mediators

Topics

• Adult
• Biomarkers (blood)
• Cytokines (blood)
• Humans
• Inflammation Mediators (blood)
• Male
• Multiple Organ Failure (complications, diagnosis, mortality)
• Multiple Trauma (blood, complications)
• Sepsis (blood, complications)
• Survival Rate
• Systemic Inflammatory Response Syndrome (complications, diagnosis, mortality)