Abstract | OBJECTIVE: To assess the effect of taurine supplementation on respiratory gas exchange, which might reflect the improved metabolism of glucose and/or lipid in the type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats. RESEARCH METHODS AND PROCEDURES: Male OLETF rats (16 weeks of age) were randomly divided into two groups: unsupplemented group and taurine-supplemented (3% in drinking water) group. After 9 weeks of treatment, indirect calorimetry and insulin tolerance tests were conducted. The amounts of visceral fat pads, tissue glycogen, the blood concentrations of glucose, triacylglycerol, taurine, and electrolytes, and the level of hematocrit were compared between groups. A nondiabetic rat strain (Long-Evans Tokushima Otsuka) was used as the age-matched normal control. RESULTS: The indirect calorimetry showed that the treatment of OLETF rats with taurine could reduce a part of postprandial glucose oxidation possibly responsible for the increase of triacylglycerol synthesis in the body. Taurine supplementation also improved hyperglycemia and insulin resistance and increased muscle glycogen content in the OLETF rats. Supplementation with taurine increased the blood concentration of taurine and electrolyte and fluid volume, all of which were considered to be related to the improvement of metabolic disturbance in OLETF rats. DISCUSSION:
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Authors | Nagakatsu Harada, Chika Ninomiya, Yoshie Osako, Masaki Morishima, Kazuaki Mawatari, Akira Takahashi, Yutaka Nakaya |
Journal | Obesity research
(Obes Res)
Vol. 12
Issue 7
Pg. 1077-84
(Jul 2004)
ISSN: 1071-7323 [Print] United States |
PMID | 15292471
(Publication Type: Journal Article)
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Copyright | Copyright 2004 NAASO |
Chemical References |
- Blood Glucose
- Electrolytes
- Insulin
- Taurine
- Glycogen
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Topics |
- Animal Nutritional Physiological Phenomena
- Animals
- Blood
- Blood Glucose
(analysis)
- Blood Pressure
- Body Weight
- Calorimetry, Indirect
- Diabetes Mellitus, Type 2
(metabolism)
- Dietary Supplements
- Drinking
- Eating
- Electrolytes
(blood)
- Food
- Glycogen
(analysis)
- Hematocrit
- Insulin
(blood)
- Insulin Resistance
- Male
- Osmolar Concentration
- Pulmonary Gas Exchange
(drug effects)
- Rats
- Rats, Inbred OLETF
- Taurine
(administration & dosage, blood)
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