Tolerance of 4-aminosalicylic acid enemas in patients with inflammatory bowel disease and 5-aminosalicylic-induced acute pancreatitis.

Abstract

Derivatives of 5-aminosalicylic acid (5-ASA) used for the treatment of inflammatory bowel disease may induce acute pancreatitis of immunoallergic origin. 4-aminosalicylic acid (4-ASA) differs from its 5-ASA counterpart by the position of the NH2 group and has shown efficacy in ulcerative colitis. The risk of cross intolerance reaction between 5-ASA and 4-ASA has currently never been evaluated. We report three cases of 5-ASA-induced pancreatitis, with no recurrence of pancreatitis during subsequent treatment with 4-ASA enemas. We conclude that 4-ASA enemas are a safe and well-tolerated therapeutic alternative whenever 5-ASA-induced pancreatitis occurs.

• Authors: Fady Daniel, Philippe Seksik, Wulfran Cacheux, Raymond Jian, Philippe Marteau
• Journal: Inflammatory bowel diseases (Inflamm Bowel Dis) Vol. 10 Issue 3 Pg. 258-60 (May 2004) ISSN: 1078-0998 [Print] England
• PMID: 15290921 (Publication Type: Case Reports, Journal Article)

Chemical References

• Mesalamine
• Aminosalicylic Acid

Topics

• Adult
• Aminosalicylic Acid (administration & dosage, adverse effects)
• Drug Tolerance
• Enema
• Female
• Humans
• Inflammatory Bowel Diseases (drug therapy)
• Male
• Mesalamine (administration & dosage, adverse effects)
• Pancreatitis, Acute Necrotizing (chemically induced)
• Treatment Outcome