Dorzolamide-induced choroidal detachment in a surgically untreated eye.

Abstract

PURPOSE:

Choroidal detachment is a known complication of topical hypotensive agents when used to treat eyes sensitized by prior surgery. We document the abrupt development of an extensive choroidal detachment after initiation of dorzolamide therapy in a surgically untreated eye with primary open-angle glaucoma.

DESIGN:

Observational case report.

METHODS:

A 76-year-old woman with primary open-angle glaucoma and no history of ocular surgery developed a choroidal detachment 12 hours after initiation of therapy with dorzolamide eye drops. Choroidal detachment was diagnosed clinically and confirmed by echography.

RESULTS:

Withdrawal of the drug and initiation of corticosteroid drops resulted in prompt resolution of the choroidal detachment.

CONCLUSIONS:

Choroidal detachment can occur in surgically untreated eyes after use of a topical carbonic anhydrase inhibitor.

• Authors: Sharon Goldberg, Ruth Gallily, Salim Bishara, Eytan Z Blumenthal
• Journal: American journal of ophthalmology (Am J Ophthalmol) Vol. 138 Issue 2 Pg. 285-6 (Aug 2004) ISSN: 0002-9394 [Print] United States
• PMID: 15289139 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antihypertensive Agents
• Carbonic Anhydrase Inhibitors
• Sulfonamides
• Thiophenes
• dorzolamide

Topics

• Aged
• Antihypertensive Agents (adverse effects)
• Carbonic Anhydrase Inhibitors (adverse effects)
• Choroid Diseases (chemically induced, diagnostic imaging)
• Female
• Glaucoma, Open-Angle (drug therapy)
• Humans
• Sulfonamides (adverse effects)
• Thiophenes (adverse effects)
• Ultrasonography