Abstract |
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by immune complex-mediated tissue injury. Many different adhesion molecules are thought to participate in the development of SLE; however, few studies have directly examined the contributions of these proteins. Here we demonstrate that LFA-1 plays an essential role in the development of lupus in MRL/MpJ-Fas(lpr) mice. Mice deficient in LFA-1, but not Mac-1, showed significantly increased survival, decreased anti- DNA autoantibody formation, and reduced glomerulonephritis. The phenotype of the LFA-1-deficient mice was similar to that observed in beta(2) integrin-deficient (CD18-null) MRL/MpJ-Fas(lpr) mice, suggesting a lack of redundancy among the beta(2) integrin family members and other adhesion molecules. These studies identify LFA-1 as a key contributor in the pathogenesis of autoimmune disease in this model, and further suggest that therapeutic strategies targeting this adhesion molecule may be beneficial for the treatment of SLE.
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Authors | Christopher G Kevil, M John Hicks, Xiaodong He, Junxuan Zhang, Christie M Ballantyne, Chander Raman, Trenton R Schoeb, Daniel C Bullard |
Journal | The American journal of pathology
(Am J Pathol)
Vol. 165
Issue 2
Pg. 609-16
(Aug 2004)
ISSN: 0002-9440 [Print] United States |
PMID | 15277234
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Autoantibodies
- CD11 Antigens
- CD18 Antigens
- Lymphocyte Function-Associated Antigen-1
- Macrophage-1 Antigen
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Topics |
- Animals
- Autoantibodies
(analysis)
- CD11 Antigens
(metabolism)
- CD18 Antigens
(metabolism)
- Glomerulonephritis
(prevention & control)
- Kidney Function Tests
- Lupus Erythematosus, Systemic
(pathology, prevention & control)
- Lymphatic Diseases
(prevention & control)
- Lymphocyte Function-Associated Antigen-1
(metabolism)
- Macrophage-1 Antigen
(metabolism)
- Mice
- Mice, Inbred C57BL
- Mice, Inbred MRL lpr
- Mice, Knockout
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