Abstract | BACKGROUND: OBJECTIVES: SEARCH STRATEGY: We searched the following electronic databases in 2003 and updated the search in 2004: the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, Issue 1, 2004); MEDLINE (January 1966 to March Week 1, 2004); EMBASE (1998 to December 2003); online databases of clinical trials; and reference lists of articles. We also contacted study authors, manufacturers and distributors of G-CSF. SELECTION CRITERIA: DATA COLLECTION AND ANALYSIS: Two reviewers independently extracted data and assessed trial quality. The primary outcome measure was 28 day mortality. Secondary outcome measures included other markers of mortality as well as markers of adverse events, including organ dysfunction. An assessment of methodological quality was made for each study. MAIN RESULTS: Six studies with a total of 1984 people were identified. G-CSF use appeared to be safe with no increase in the incidence of total serious adverse events (pooled odds ratio (OR) 0.91; 95% confidence interval (CI): 0.73 to 1.14) or organ dysfunction. However, the use of G-CSF was not associated with improved 28 day mortality (pooled OR 0.86; 95% CI: 0.56 to 1.31). REVIEWERS' CONCLUSIONS: There is no current evidence supporting the routine use of G-CSF in the treatment of pneumonia. Studies in which G-CSF is administered prophylactically or earlier in therapy may be of interest.
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Authors | A C Cheng, D P Stephens, B J Currie |
Journal | The Cochrane database of systematic reviews
(Cochrane Database Syst Rev)
Issue 3
Pg. CD004400
( 2004)
ISSN: 1469-493X [Electronic] England |
PMID | 15266532
(Publication Type: Journal Article, Review, Systematic Review)
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Chemical References |
- Recombinant Proteins
- Granulocyte Colony-Stimulating Factor
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Topics |
- Adult
- Chemotherapy, Adjuvant
- Community-Acquired Infections
(drug therapy, mortality)
- Granulocyte Colony-Stimulating Factor
(therapeutic use)
- Humans
- Pneumonia
(drug therapy, mortality)
- Randomized Controlled Trials as Topic
- Recombinant Proteins
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