HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Residential exposure to volatile organic compounds and asthma.

Abstract
We critically analysed the literature concerning exposure to volatile organic compounds and asthma. Observational studies have consistently found a relation between volatile organic compounds and indicators of asthma, such as symptoms, peak flows, and objectively measured bronchial reactivity. In contrast, interventional studies have generally failed to find a relation between exposure to residential levels of formaldehyde and other volatile organic compounds and asthma. One hypothesis to explain the discrepancy in findings between interventional and observational studies is that the effect size is small requiring relatively large numbers of study subjects, common in observational studies but often not feasible in interventional studies. Another hypothesis is that longer duration of exposure is important, a common circumstance in observational studies where the home environment is the exposure setting. In contrast, duration of exposure in interventional studies is usually of minutes-to-hours in a chamber. Finally, the observed association in observational studies could be confounded by a factor which is a determinant of asthma and is also associated with exposure to volatile organic compounds.
AuthorsRobert Dales, Mark Raizenne
JournalThe Journal of asthma : official journal of the Association for the Care of Asthma (J Asthma) Vol. 41 Issue 3 Pg. 259-70 ( 2004) ISSN: 0277-0903 [Print] England
PMID15260458 (Publication Type: Journal Article, Review)
Chemical References
  • Organic Chemicals
Topics
  • Air Pollution, Indoor (adverse effects)
  • Asthma (chemically induced, physiopathology)
  • Epidemiologic Research Design
  • Humans
  • Inhalation Exposure (adverse effects)
  • Organic Chemicals (adverse effects)
  • Residence Characteristics
  • Volatilization

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: