[Fixed drug eruption induced by sulfaguanidine].

Abstract

INTRODUCTION:

Fixed drug eruption is a lesion induced by drugs. The family of drugs usually incriminated are sulfonamides, tetracyclines and pyrazols. We describe nine cases of fixed drug eruption induced by sulfaguanidine, a sulfonamide with local action.

CASE REPORTS:

All the patients presented one or more fixed drug eruption reactivation lesions induced by sulfaguanidine as self-medication for diarrhea. The number of lesions increased in 7 cases after reactivation. The delay in occurrence of the fixed drug eruption decreased during the different episodes. The lesions predominated on the hands in 8 cases of 9.

DISCUSSION:

The sulfaguanidine must be added to the list of drug-induced fixed drug eruptions with limited absorption from the gastrointestinal tract.

• Authors: S Kastalli, S El Aidli, R Daghfous, S Trabelsi, M Lakhal, M-H Loueslati, C Belkahia
• Journal: Annales de dermatologie et de venereologie (Ann Dermatol Venereol) Vol. 131 Issue 4 Pg. 382-4 (Apr 2004) ISSN: 0151-9638 [Print] France
• Vernacular Title: Erythème pigmenté fixe à la sulfaguanidine.
• PMID: 15258515 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Infective Agents
• Sulfaguanidine

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Anti-Infective Agents (adverse effects)
• Drug Eruptions (etiology, pathology)
• Erythema (chemically induced, pathology)
• Female
• Humans
• Male
• Middle Aged
• Sulfaguanidine (adverse effects)