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Mammalian sensitivity to elemental gold (Au degrees).

Abstract
There is increasing documentation of allergic contact dermatitis and other effects from gold jewelry, gold dental restorations, and gold implants. These effects were especially pronounced among females wearing body-piercing gold objects. One estimate of the prevalence of gold allergy worldwide is 13%, as judged by patch tests with monovalent organogold salts. Eczema of the head and neck was the most common response of individuals hypersensitive to gold, and sensitivity can last for at least several years. Ingestion of beverages containing flake gold can result in allergic-type reactions similar to those seen in gold-allergic individuals exposed to gold through dermal contact and other routes. Studies with small laboratory mammals and injected doses of colloidal gold showed increased body temperatures, accumulations in reticular cells, and dose enhancement in tumor therapy; gold implants were associated with tissue injuries. It is proposed that Au degrees toxicity to mammals is associated, in part, with formation of the more reactive Au+ and Au3+ species.
AuthorsRonald Eisler
JournalBiological trace element research (Biol Trace Elem Res) Vol. 100 Issue 1 Pg. 1-18 (Jul 2004) ISSN: 0163-4984 [Print] United States
PMID15258315 (Publication Type: Case Reports, Journal Article, Review)
Chemical References
  • Antirheumatic Agents
  • Cations
  • Gold Alloys
  • Gold Colloid
  • Gold
Topics
  • Animals
  • Antirheumatic Agents (adverse effects)
  • Body Piercing
  • Cations
  • Dermatitis, Allergic Contact (diagnosis, epidemiology, etiology)
  • Female
  • Gold (adverse effects, immunology, toxicity)
  • Gold Alloys
  • Gold Colloid (toxicity)
  • Humans
  • Male
  • Ossicular Prosthesis
  • Patch Tests
  • Prevalence

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