Evaluation of intestinal clearance and faecal excretion of alpha 1-antiproteinase and immunoglobulins during Crohn's disease and ulcerative colitis.

The intestinal clearance of alpha 1-antiproteinase, monomeric IgA and IgG, and the daily fecal output of polymeric IgA and IgM were investigated in patients with inflammatory bowel diseases (inactive and active Crohn's disease, ulcerative colitis) and in a control group. The intestinal clearance of alpha 1-antiproteinase was significantly increased in all patients with inflammatory bowel diseases (p less than 0.01), irrespective of the grade of the disease. In contrast, increases in intestinal clearances of monomeric IgA and IgG were more closely related to the severity of the intestinal lesions. The associate determination of these three quantities should therefore be of interest for monitoring the degree of intestinal bowel inflammation. Faecal output of polymeric IgA was significantly increased in active intestinal disease (p less than 0.01), whereas faecal IgM levels were not. The determination of the faecal output of polymeric IgA should contribute to the assessment of the activity of inflammatory bowel diseases, and may provide insight into the activation of the mucosal immune system.
AuthorsN Kapel, D Meillet, L Favennec, D Magne, D Raichvarg, J G Gobert
JournalEuropean journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies (Eur J Clin Chem Clin Biochem) Vol. 30 Issue 4 Pg. 197-202 (Apr 1992) ISSN: 0939-4974 [Print] GERMANY
PMID1525248 (Publication Type: Journal Article)
Chemical References
  • Immunoglobulin A
  • Immunoglobulins
  • Polymers
  • alpha 1-Antitrypsin
  • polymeric IgA
  • Adolescent
  • Adult
  • Aged
  • Child
  • Colitis, Ulcerative (immunology, metabolism)
  • Crohn Disease (immunology, metabolism)
  • Feces (chemistry)
  • Female
  • Humans
  • Immunoglobulin A (metabolism)
  • Immunoglobulins (metabolism)
  • Intestinal Mucosa (immunology, metabolism)
  • Male
  • Middle Aged
  • Polymers
  • alpha 1-Antitrypsin (metabolism)

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