Evaluation of systemic inflammatory responses in neonates with herpes simplex virus infection.

Abstract

Neonatal herpes simplex virus (HSV) infection is a severe disease with high mortality and morbidity. To investigate the pathogenesis of neonatal HSV infection, we examined inflammatory responses and markers of apoptosis in patients with neonatal HSV infection. Concentrations of inflammatory cytokines and markers of apoptosis were significantly higher in patients with disseminated HSV infection and were correlated with HSV load. It appears that the immunopathological damage that results from host responses to viral infection leads to organ dysfunction in patients with neonatal HSV infection.

• Authors: Jun-ichi Kawada, Hiroshi Kimura, Yoshinori Ito, Yoshihiro Ando, Naoko Tanaka-Kitajima, Masahiro Hayakawa, Hiroyuki Nunoi, Fumio Endo, Tsuneo Morishima
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 190 Issue 3 Pg. 494-8 (Aug 01 2004) ISSN: 0022-1899 [Print] United States
• PMID: 15243922 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Immunoglobulin G
• Interleukin-6
• Receptors, Tumor Necrosis Factor
• Etanercept

Topics

• Apoptosis
• Etanercept
• Herpes Simplex (immunology, mortality, physiopathology, virology)
• Humans
• Immunoglobulin G (blood)
• Infant, Low Birth Weight
• Infant, Newborn
• Infant, Premature
• Infant, Premature, Diseases (immunology, mortality, physiopathology, virology)
• Interleukin-6 (blood)
• Receptors, Tumor Necrosis Factor (blood)
• Simplexvirus (genetics, isolation & purification, physiology)
• Systemic Inflammatory Response Syndrome (immunology, mortality, physiopathology, virology)
• Viral Load