HIV and drug allergy.

Abstract

Twenty individual antiretroviral drugs and two coformulation products are approved by the US Food and Drug Administration for the treatment of HIV-infected individuals. Many of these drugs have been associated with allergic/hypersensitivity reactions to varying degrees. The antiretroviral drugs that are most commonly associated with these types of reactions are abacavir, all of the nonnucleoside reverse transcriptase inhibitors, and amprenavir. Trimethoprim-sulfamethoxazole, although not an antiretroviral drug, is extensively used for the treatment and prophylaxis of HIV-related opportunistic infections and has been associated with a significant rate of adverse reactions. The authors provide an overview of these drug-related reactions and discuss their pathogenesis and management.

• Authors: Zelalem Temesgen, Gagan Beri
• Journal: Immunology and allergy clinics of North America (Immunol Allergy Clin North Am) Vol. 24 Issue 3 Pg. 521-31, viii (Aug 2004) ISSN: 0889-8561 [Print] United States
• PMID: 15242725 (Publication Type: Journal Article, Review)

Chemical References

• Antiviral Agents

Topics

• Antiviral Agents (adverse effects, immunology, therapeutic use)
• Drug Hypersensitivity (immunology, physiopathology)
• HIV Infections (complications, drug therapy)
• Humans